Post-translational control of Nur77.
نویسندگان
چکیده
Nur77 is a nuclear orphan receptor that has been implicated in both cell survival and apoptosis. With the exception of T-cells, translocation of Nur77 to the cytoplasm promotes cell death, while its retention in the nucleus promotes survival and proliferation. Nur77 appears to be a true orphan receptor, indicating that its activity must be controlled by ligand-independent mechanisms. Here, we discuss the role of phosphorylation in the regulation of Nur77.
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 34 Pt 6 شماره
صفحات -
تاریخ انتشار 2006